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腺瘤性結腸息肉病蛋白2抗體

文字:[大][中][小] 2017-5-4    瀏覽次數:1328    

                                                       腺瘤性結腸息肉病蛋白2抗體                                                                                                                                                
英文名稱  Anti-APCL/APC2 
中文名稱  腺瘤性結腸息肉病蛋白2抗體 
別    名  Adenomatous polyposis coli protein 2; Adenomatous polyposis coli protein-like; APCL; APC2_HUMAN. 

詳細介紹:


濃    度  1mg/1ml 
規 格  0.2ml/200μg   
抗體來源  Rabbit  
克隆類型  polyclonal 
交叉反應  Human, Mouse, Rat, Dog, Pig, Horse  
產品類型  一抗    
研究領域  腫瘤 免疫學 細胞粘附分子 細胞骨架  
蛋白分子量  predicted molecular weight: 244kDa 
性    狀  Lyophilized or Liquid 
免 疫 原  KLH conjugated synthetic peptide derived from human APCL/APC2 
亞    型  IgG 
純化方法  affinity purified by Protein A 
儲 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 
產品應用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500 
(石蠟切片需做抗原修復) 
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user.  
保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

相關資料:


產品介紹 The adenomatous polyposis syndromes, familial adenomatous polyposis (FAP) and Gardner’s syndrome (GS), are characterized by numerous adenomatous polyps throughout the entire colon. These polyps invariably progress to colon cancer in addition to other extracolonic manifestations. The cloning of the APC gene revealed a ubiquitously expressed protein, 2843 amino acids in length, which is frequently mutated in patients suffering from FAP and GS. APC has been found to be associated with structural components of intracellular junctions. b-catenin and g-catenin (also called plakoglobin) are involved in the regulation of cellular adhesion. APC and E cadherin compete for binding to specific internal regions of both b- and g-catenin. Interactions between cytoskeleton and the APC, E cadherin, b/g catenin complex are mediated by a-catenin. 
Function : APC2 might function in the Wnt signaling pathway through it's ability to promote the rapid degradation of beta-catenin. It also functions as a tumour suppressor.
Subunit : Interacts with PSRC1 (By similarity). Interacts with APC, CTNNB1, MAPRE1, MAPRE3, TP53BP2 and possibly with AXIN2. 
Subcellular Location : Cell Membrane, Cytoplasmic and Golgi Apparatus
Tissue Specificity : Widely expressed (at protein level). Specifically expressed in the CNS. 
Similarity : Belongs to the adenomatous polyposis coli (APC) family. 
Contains 6 ARM repeats. 
Database links : UniProtKB/Swiss-Prot: O95996.1

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