欧美日韩三区四区_试看120秒一区二区三区_亚洲一区二区在线观看视频_久久综合色88

今天是2025年8月6日 星期三,歡迎光臨本站 上海研生實業有限公司 網址: www.845158.com

一抗

細胞周期后期促進蛋白亞基11抗體

文字:[大][中][小] 2017-5-4    瀏覽次數:1195    

                                                       細胞周期后期促進蛋白亞基11抗體                                                                                                                                                
英文名稱  Anti-APC11 
中文名稱  細胞周期后期促進蛋白亞基11抗體 
別    名  ANAPC 11; ANAPC11; Anaphase promoting complex subunit 11; Anaphase promoting complex subunit 11 homolog (yeast); Anaphase promoting complex subunit 11 homolog; Anaphase-promoting complex subunit 11; Apc 11; Apc 11p; APC11 anaphase promoting complex subunit 11 homolog (yeast); APC11 anaphase promoting complex subunit 11 homolog; APC11; APC11_HUMAN; Apc11p; Cyclosome subunit 11; Hepatocellular carcinoma associated RING finger protein; Hepatocellular carcinoma-associated RING finger protein; HSPC 214; HSPC214; MGC882; Yeast APC 11 homolog; Yeast APC11 homolog. 

詳細介紹:


濃    度  1mg/1ml 
規 格  0.2ml/200μg   
抗體來源  Rabbit  
克隆類型  polyclonal 
交叉反應  Human, Mouse, Rat, Dog, Pig, Sheep
產品類型  一抗    
研究領域  細胞生物 細胞周期蛋白 泛素  
蛋白分子量  predicted molecular weight: 10kDa 
性    狀  Lyophilized or Liquid 
免 疫 原  KLH conjugated synthetic peptide derived from human APC11 
亞    型  IgG 
純化方法  affinity purified by Protein A 
儲 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 
產品應用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500 
(石蠟切片需做抗原修復) 
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user.  
保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

相關資料:


產品介紹 Comprising more than ten subunits, the anaphase-promoting complex (APC) acts in a cell-cycle dependent manner to promote the separation of sister chromatids during the transition between metaphase and anaphase in mitosis. APC, or cyclosome, accomplishes this progression through the ubiquitination of mitotic cyclins and other regulatory proteins that are targeted for destruction during cell division. APC is phosphorylated, and thus activated, by protein kinases Cdk1/cyclin B and polo-like kinase (Plk). APC is under tight control by a number of regulatory factors, including CDC20, CDH1 and MAD2. Specifically, CDC20 and CDH1 directly bind to APC and activates APC’s cyclin-ubiquitination activity. In contrast, MAD2 inhibits APC by forming a ternary complex with CDC20 and APC; thus preventing APC activation. APC11 is a RING-H2 finger protein that allows for the synthesis of multiubiquitin chains in the presence of Ubiquitin carrier protein 4 (Ubc4) and ubiquitin conjugating enzyme (E2). In addition, a heterodimeric complex of either Ubc4 or UbcH10 with APC11 and APC2 catalyzes the ubiquitination of human securin and cyclin B1. 
Function : Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.
Subunit : The APC/C is composed of at least 12 subunits. Interacts with the cullin domain of ANAPC2. Interacts with UBE2D2. 
Subcellular Location : Cytoplasm. Nucleus.
Tissue Specificity : Expressed at high levels in skeletal muscle and heart; in moderate levels in brain, kidney, and liver; and at low levels in colon, thymus, spleen, small intestine, placenta, lung and peripheral blood leukocyte.
Post-translational modifications : Auto-ubiquitinated.
Similarity : Belongs to the RING-box family.
Contains 1 RING-type zinc finger.
Database links : UniProtKB/Swiss-Prot: Q9NYG5.1

返回上一步
打印此頁
[向上]

網站首頁

公司介紹

產品中心

技術服務

技術文獻

在線留言

聯系我們

在線客服

售前咨詢

售后服務

咨詢電話:
021-59989018

請掃描二維碼
打開手機站

主站蜘蛛池模板: 河池市| 永春县| 晋中市| 湟源县| 全州县| 金沙县| 谷城县| 柳林县| 柘荣县| 梁山县| 淄博市| 襄汾县| 霍城县| 富蕴县| 丰都县| 敦煌市| 巴彦县| 水富县| 温泉县| 蒙自县| 江北区| 罗平县| 万山特区| 绥德县| 阜新市| 湟中县| 区。| 天等县| 芜湖市| 晴隆县| 天水市| 辽中县| 洛宁县| 湖南省| 嘉兴市| 鄢陵县| 同心县| 香格里拉县| 鲁山县| 伊通| 旅游|