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英文名稱(chēng)Anti-Amisyn/FITC
中文名稱(chēng):FITC標(biāo)記的突觸融合結(jié)合蛋白6抗體
別 名Amisyn; HSPC156; STXB6_HUMAN; STXBP6; Syntaxin binding protein 6; Syntaxin-binding protein 6.
規(guī)格:100ul
說(shuō) 明 書(shū)100ul
研究領(lǐng)域神經(jīng)生物學(xué) 細(xì)胞粘附分子 細(xì)胞外基質(zhì)
抗體來(lái)源Rabbit
克隆類(lèi)型Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Cow, Rabbit, Sheep,
產(chǎn)品應(yīng)用ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量24kDa
細(xì)胞定位細(xì)胞膜
性 狀Lyophilized or Liquid
濃 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Amisyn
亞 型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹background:
Amisyn is a mostly cytosolic protein related to Tomosyn which plays an important role in SNARE complex assembly. Amisyn contains a v-SNARE coiled coil homology domain that binds to Syntaxin 1A and weakly to Syntaxin 4. Three isoforms exist for Amisyn. Isoform 1 is the full length protein, isoform 2 has a different amino acid sequence between residues 204-210 and isoform 3 is missing amino acids 1-102 and contains a different sequence for amino acids 103-150. Amisyn lacks a transmembrane domain and therefore is unable to assemble into a functional, membrane-anchored SNARE complex. This suggests that Amisyn may instead be acting to maintain SNARE conformation and facilitate the binding of VAMP-2. Amisyn can inhibit exocytosis independent of Syntaxin binding
Function:
Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis.
Subunit:
Part of a ternary complex containing SNAP25 and STX1A that can be dissociated by NAPA and NSF. Interacts with STX4A.
Subcellular Location:
Cytoplasm. Membrane.
Tissue Specificity:
Detected at low levels in brain, and at very low levels in heart, adrenal gland, testis, liver and kidney.
Similarity:
Contains 1 v-SNARE coiled-coil homology domain.
中文名稱(chēng):FITC標(biāo)記的突觸融合結(jié)合蛋白6抗體
別 名Amisyn; HSPC156; STXB6_HUMAN; STXBP6; Syntaxin binding protein 6; Syntaxin-binding protein 6.
詳細(xì)介紹：
規(guī)格:100ul
說(shuō) 明 書(shū)100ul
研究領(lǐng)域神經(jīng)生物學(xué) 細(xì)胞粘附分子 細(xì)胞外基質(zhì)
抗體來(lái)源Rabbit
克隆類(lèi)型Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Cow, Rabbit, Sheep,
產(chǎn)品應(yīng)用ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量24kDa
細(xì)胞定位細(xì)胞膜
性 狀Lyophilized or Liquid
濃 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Amisyn
亞 型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
相關(guān)資料：
產(chǎn)品介紹background:
Amisyn is a mostly cytosolic protein related to Tomosyn which plays an important role in SNARE complex assembly. Amisyn contains a v-SNARE coiled coil homology domain that binds to Syntaxin 1A and weakly to Syntaxin 4. Three isoforms exist for Amisyn. Isoform 1 is the full length protein, isoform 2 has a different amino acid sequence between residues 204-210 and isoform 3 is missing amino acids 1-102 and contains a different sequence for amino acids 103-150. Amisyn lacks a transmembrane domain and therefore is unable to assemble into a functional, membrane-anchored SNARE complex. This suggests that Amisyn may instead be acting to maintain SNARE conformation and facilitate the binding of VAMP-2. Amisyn can inhibit exocytosis independent of Syntaxin binding
Function:
Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis.
Subunit:
Part of a ternary complex containing SNAP25 and STX1A that can be dissociated by NAPA and NSF. Interacts with STX4A.
Subcellular Location:
Cytoplasm. Membrane.
Tissue Specificity:
Detected at low levels in brain, and at very low levels in heart, adrenal gland, testis, liver and kidney.
Similarity:
Contains 1 v-SNARE coiled-coil homology domain.
