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中藥標(biāo)準(zhǔn)品
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產(chǎn)品編號(hào) |
英文名稱 |
CAS號(hào) |
包裝 |
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Y3641 |
Indirubin |
479-41-4 |
可根據(jù)客戶要求訂制 |
英文名稱：Indirubin
CAS號(hào)：479-41-4
分析標(biāo)準(zhǔn)品,≥95%
分子式 C16H10N2O2 分子量262.26
基本信息:
敏感性 對(duì)熱敏感
密度 1.417
溶解性 Soluble in DMSO(warmed) (>2 mg/ml).
存貯條件 儲(chǔ)存溫度2-8℃
描述
產(chǎn)品介紹 Indirubin, also known as isoindigotin, is an inhibitor of cyclin-dependent kinases (CDK1/cyclin B (IC50 = 10μM), CDK2/cyclin A (IC50 = 2.2μM), CDK2/cyclin E (IC50 = 7.5μM), CDK4/cyclin D1 (IC50 = 12μM), CDK5/p35 (IC50 = 5.5μM)) and of GSK-3β (IC50 = 600nM). Studies investigating functional isoindigos show that they have the ability to disrupt cell growth and proliferation. The compound is a potent aryl hydrocarbon receptor ligand and is found in human urine and fetal bovine serum. Synthesized isoindigo-based oligothiophenes are used to study heterojunction solar cells. Shown to inhibit allergic contact dermatitis by regulating T helper mediated immune system in a DNCB-induced model.
別名 靛紅 ;Indigo Red; Isoindogotin
應(yīng)用 An inhibitor of GSK-3β and cyclin-dependent kinases.
